Below is Dave Campbell's Texas Football's and TexasFootball.com's final regular season ranking for Class 2A-DI. The rankings will have one final adjustment after the state title games.
| 2012 Week Ten Rankings | ||||
| CLASS 2A-DI |
| Rank | School (Last week) | 2012 Overall/District Record | Previous result |
| 1 | Cameron Yoe (1) | 10-0/6-0 | W, 56-0, Florence |
| 2 | Newton (2) | 10-0/6-0 | W, 51-7, Woodville |
| 3 | New Boston (3) | 10-0/6-0 | W, 56-21, Mount Vernon |
| 4 | Hallettsville (4) | 10-0/5-0 | W, 22-19, Hempstead |
| 5 | Wall (5) | 9-1/6-0 | W, 73-6, Ingram Moore |
| 6 | Pottsboro (7) | 10-0/6-0 | Idle |
| 7 | San Diego (8) | 10-0/6-0 | W, 21-14, Falfurrias |
| 8 | Idalou (10) | 8-2/5-0 | W, 52-6, Lamesa |
| 9 | Grandview (NR) | 8-2/6-0 | W, 28-14, Godley |
| 10 | Littlefield (NR) | 8-2/5-0 | W, 51-42, Muleshoe |
Dropped out: No. 6 Godley (L, 28-14, Grandview), No. 9 Muleshoe (L, 51-42, Littlefield)
